TB – Mycobacterium tuberculosis

Mycobacterium tuberculosis (Redirected from TB)

Mycobacterium Tuberculosis, better known as the bacteria that causes TB, is an infectious bacteria infects the lungs, brain, and spine. The examination of clinical specimens from infected humans and animals shows the variable patterns of pathological reactions in different species. Guinea pigs are innately susceptible while humans, mice and rabbits show different level of resistance depending upon their genotype. Not every infection causes clinical symptoms, therefore, the distinction between carriers (Latent TB) and TB disease is crucial. If untreated, the disease can be fatal in humans. Not long ago, TB was a leading cause of death in the US and worldwide, however, now most cases can be cured with antibiotic treatment.


TB bacteria spread through the air from an infected person to another person. The TB bacteria disperse through the air when a person with TB disease of the lungs or throat coughs, speaks or sings. People nearby may breathe in these bacteria and become infected. Infection of the lungs or throat spread quicker as a result. The bacteria do not spread on surfaces or from direct contact such as shaking hands.

Symptoms in Humans:

Signs and symptoms will vary depending on the region of the body that is infected. However, pulmonary infection (lung infection) is the most prevalent. These include:

  • A cough lasting 3 weeks or longer
  • chest pain
  • Coughing up blood
  • Feeling weak or very tired
  • Unexplained weight loss
  • Chills
  • Fever
  • Sweating at night
  • Having no appetite

In Guinea Pigs:

Guinea pigs are naturally susceptible to infection with either Mycobacterium tuberculosis or M bovis. Lesions can be seen in the parenchyma of the lung and adjacent lymph nodes. Other clinical signs including abnormal fur texture and lethargy. Guinea pigs with dormant infection steadily gained weight and presented no clinical signs of active disease.

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