Controlling Pinworms in Research Vivariums

Controlling Pinworm In Research Vivariums

Pinworms are nematode parasites which frequently infect colonies of laboratory mice and can pose a serious threat to both germ-free and conventional murine research models in vivariums and research facilities. Pinworms, which are small intestinal parasites, have a life cycle that can be completed in as little as 11-15 days. Gravid females migrate from the large intestine to the perianal area, deposit their eggs, and then die. These eggs become infective in about 6 hours and can survive for weeks under most animal room conditions. Once ingested by another host, the larvae reach the cecum in 24 hours, where they continue to mature and mate, thus continuing the cycle. Laboratory mice, rats, hamsters, gerbils, and wild rodents can all be affected by pinworm infestations, and the parasites are most commonly found in the cecum and colon of infected hosts.

While pinworms of laboratory rodents are generally not considered pathogens, the burden of these parasites in an infected rodent population can be significant. Pinworm infections can interfere with research outcomes, for example by reducing the occurrence of adjuvant-induced arthritis in rats. In this article, we will explain the best methods for remediation and how QuipDecon services can help take the burden of pinworm remediation off of our customer’s shoulders, while ensuring that it’s being done correctly to minimize the risk of unnecessary disruptions to research outcomes.

How Do Pinworm Outbreaks Affect Research Outcomes?

Pinworms, particularly the murine pinworm Syphacia muris, are a common parasite that infests research vivariums. As a research facility manager, you know that the health and safety of your animals is of utmost importance, and these parasites not only pose a health risk to mice and rats but can also negatively impact research outcomes and create a significant operational burden on facility care staff.

In one 2006 study, researchers demonstrated the consequence of an outbreak in a transgenic mouse facility of infection with a common, highly contagious, rapidly spreading mouse nematode parasite, the pinworm (S. obvelata). Several gene-deficient mouse strains became severely and chronically infected. These researchers defined S. obvelata-induced host immune responses and showed evidence for protective type 2 responses, with IL-13 (but not IL-4) being essential for resistance and parasite control. They also provided experimental data demonstrating that S. obvelata infection could alter the outcome of an unrelated experiment, i.e., ovalbumin-induced allergic reactions.

pinworm remediation

Can My Staff Handle Pinworm Remediation?

Whether or not your staff can handle pinworm remediation is entirely dependent on the resources at your disposal. Pinworm remediation requires a significant amount of training in order to do properly, and there will need to be verification methods used to determine how effective the remediation was. All of that can add up to a significant burden on your staff, taking valuable time and resources away from day-to-day animal care tasks.

For those looking to manage pinworm remediation on their own, a 2014 study published in JAALAS found a 99.7% kill rate for Syphacia muris eggs from gaseous chlorine dioxide, indicating that it can be an effective tool for controlling pinworm numbers. Another study conducted by GlaxoSmithKline Pharmaceuticals found that chlorine dioxide treatments showed marked effectiveness in destroying Syphacia muris eggs.

These studies show that, with the right tools and strategies in place, pinworm infestations in research facilities can be effectively managed. One such tool that has shown promise is the MB-10 Chlorine Dioxide Tablets (when following use-instructions for surface sterilization), which generate chlorine dioxide when mixed with water and have been shown to be effective against pinworm eggs. However, facilities looking to manage pinworm remediation should also have a variety of protocols in place to ensure a comprehensive kill, safety when using chlorine dioxide at sterilant ppm (including using a self-contained breathing apparatus) and thorough post-decon process to determine whether remediation was successful. That’s why we typically recommend using a decontamination service like QuipDecon. Our specialized decontamination services can help take the burden of pinworm remediation off your shoulders, while ensuring that it’s being done correctly.

What Does QuipDecon Include?

Our QuipDecon team uses a variety of proprietary disinfection methods, tailored to your facility’s specific needs, to ensure that all pinworms and their eggs are eliminated. And with our advanced technologies and techniques, we can guarantee that our services will not compromise the integrity of your research outcomes.

By partnering with QuipDecon, you can rest easy knowing that your animals are safe from pinworms, and that your research outcomes will not be impacted by unnecessary risks. Let us help you protect your animals and your research.

Our QuipDecon Decontamination Services are comprised of multiple components, including Quip Laboratories’ proprietary chemistries, state-of-the-art equipment, and proven methodologies for design, monitoring, testing, and education of both facility staff and researchers. This allows you to create a safe environment for your facility without putting stress on your employees, reduce liability when a facility is no longer needed, control research-associated infections and pathogen outbreaks in research models better, and validate cleaning and disinfection for regulatory or institutional requirements.

Our QuipDecon services utilize a range of disinfection methods that are tailored to the specific needs of each facility. While we do offer full service, turnkey solutions for remediation, we also understand that every environment is unique, which is why we work closely with our clients to develop customized disinfection plans that address their specific concerns. Our highly trained technicians have access to the latest equipment and technologies to ensure that we provide the most effective decontamination services possible. Whether you require disinfection services for research facilities, healthcare facilities, or other spaces, we have the expertise and experience to meet your needs. If you’re interested in learning more about our pinworm remediation services, please don’t hesitate to reach out. Our QuipDecon Team is always happy to answer any questions you may have.

Need a Help Managing Pinworm?

Our QuipDecon Services Can Help. Contact Us Using the Button Below to Get Started!

Need More Help With Your Chemicals?

Need more help? Fill out the form below to get connected to a Biosafety Account Manager Now.

  • Live outside the US? You'll want to use our International Contact Form.
  • Provide a short word or phrase to get a faster, more detailed response
  • You can leave a more detailed question here
  • This field is for validation purposes and should be left unchanged.