Ebola Virus

Ebola Virus

Ebola Virus
Ebola Virus Disease (EVD) is a rare and deadly disease most commonly affecting people and nonhuman primates (monkeys, gorillas, and chimpanzees). EBOV carries a negative-sense RNA genome in virions that are cylindrical/tubular, and contain viral envelope, matrix, and nucleocapsid components. Being acellular, viruses such as Ebola do not replicate through any type of cell division; rather, they use a combination of host- and virally encoded enzymes, alongside host cell structures, to produce multiple copies of themselves.


The mode of transmission for the Ebola Virus has not been identified, however, scientists believe that the first patients typically become infected through contact with an infected animal, such as a fruit bat, apes or monkeys.When an infection occurs in humans, the virus can be spread to others through blood or bodily fluids such as urine, saliva, sweat, feces, vomit, breast milk and semen. Objects and surfaces that have been contaminated with bodily fluids from a person who is sick with Ebola can also be carriers of the virus.


It can be difficult to clinically distinguish ebola virus from other infectious diseases such as malaria, typhoid fever, meningitis and other viral haemorrhagic fevers. Symptoms include, but are not limited to: high fever, headache, joint and muscle aches, sore throat, weakness, stomach pain and lack of appetite.

Confirmation that symptoms are caused by Ebola virus infection are made using the following diagnostic methods:

  • antibody-capture enzyme-linked immunosorbent assay (ELISA)
  • antigen-capture detection tests
  • serum neutralization test
  • reverse transcriptase polymerase chain reaction (RT-PCR) assay
  • electron microscopy
  • virus isolation by cell culture.

Because Ebola is a tightly controlled virus, testing for surrogates is often necessary. You can find information about the Quip Labs products recommended for Ebola HERE. 

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