Home » Corynebacterium bovis

Corynebacterium bovis

Cornyebacterium bovis

Corynebacterium bovis, a Gram-positive pathogen, triggers “scaly skin disease” in nude mice and impacts cattle with mastitis, pyelonephritis, and cream rancidity. Its threats extend to research labs, affecting immunocompromised lab animals with symptoms ranging from diarrhea to mortality, causing project delays, extra costs, and data concerns. The bacterium spreads via contact and fomites. In mice, C. bovis prompts hyperkeratosis marked by adherent yellow-white flakes on thickened skin, leading to scaly appearance, weight loss, and challenges in tumor growth and immunologic studies. Though mortality is low, hyperkeratosis can recur. Quip Labs’ QuipDecon Services utilize specialized chemistries, equipment, and methods for effective decontamination, minimizing disruptions while securing against C. bovis risks, thus maintaining research integrity.

How does c. bovis affect research labs?

C. bovis can have a significant impact on research labs, particularly those working with immunocompromised lab animal species. Infections can cause diarrhea, weight loss, reduced fertility, and even death in affected animals. In addition to the direct impact on lab animal health, C. bovis outbreaks can also lead to project delays, additional costs for treatment and decontamination, and potential negative impacts on research data.

Transmission:  The bacterium is carried on the skin and in the oral cavity of mammals, and is transmitted by direct contact and by fomite transmission (handling, flake contact, etc.). The primary means of entrance of C. bovis into vivaria is often unknown, although several reservoirs of the bacterium have been suggested. Fomites and keratin flakes often are implicated in the transmission of the bacterium, but demonstration and extent of cross-contamination in an experimental setting have not been documented.

Pathology and Diagnosis: Short, Gram-positive rods arranged in clusters and pallisades can be recognized in the stratum corneum on Gram-stained skin sections.

The bacterium can be detected in skin samples by a C. bovis-specific PCR test. Plated bacteria can be identified from the environment using DNA or Mald-Tof Sequencing. The bacterium can also be cultured by inoculating blood agar with skin or buccal swabs.

 

Products With Claim

May not represent all products with this claim. For more, please sort all products by using the button below.

Decontaminating Against C. Bovis

QuipDecon Services by Quip Labs can play a critical role in eradicating C. Bovis from research labs or vivariums, particularly among murine species. Our decontamination services leverage our proprietary chemistries, state-of-the-art equipment and proven methodologies, and we’ll make sure that there’s very little operational interruption, and that all proper decontamination and verification steps are taken to eliminate the risks to research that C. Bovis poses.

More About QuipDecon Services

Clinical signs:

In Mice: C. bovis is usually manifested as a hyperkeratosis with yellow-white flakes adherent to thickened skin.

Infection is characterized by a scaly appearance due to the presence of small yellow-white flakes adherent to the skin, most prominent along the dorsum and often extending laterally to the flanks. Affected mice may lose weight and are often removed from study because of reports of poor growth of transplanted tumors or hindrance of immunologic studies. Mortality is low and the hyperkeratosis is transient but may recur.  Mice may be persistently colonized, even without displaying clinical signs.  C. bovis has also been cultured from skin of asymptomatic hisute immunocompetent mice.

In Cattle: Cysticercus bovis is not pathogenic for cattle and usually the infection causes no clinical signs, unless a vital organ (e.g. the heart) is massively infected, which is very unsusual. In case of massive infections muscle stiffness has been reported. However, infections have a substantial economic impact because the whole carcass is condemned at slaughter. Proper disinfection procedures, including the use of effective post-milking teat disinfectants in cattle facilities, will help to reduce the number of new infections.

 

Frequently Asked Questions About C. Bovis

Q: What is C. Bovis?

A: Corynebacterium bovis (C. bovis) is a Gram-positive, non-spore-forming bacterium commonly encountered in athymic nude mouse colonies at academic and industry vivaria. This pathogen poses a significant challenge to the research community due to its persistence and resistance to eradication efforts.

Q: How does C. Bovis affect research labs?

A: C. bovis can have a significant impact on research labs, particularly those working with immunocompromised lab animal species. Infections can cause diarrhea, weight loss, reduced fertility, and even death in affected animals. In addition to the direct impact on lab animal health, C. bovis outbreaks can also lead to project delays, additional costs for treatment and decontamination, and potential negative impacts on research data.

Q: Why is it important to prevent and eradicate C. Bovis?

A: Preventing and eradicating C. Bovis is crucial for maintaining the health of lab animal populations and ensuring the integrity of research data. Outbreaks can have serious consequences for animal welfare, scientific progress, and financial resources. By implementing best practices for facility hygiene, using disinfectants with C. bovis label claims, and following established protocols for decontamination, researchers and facility managers can help prevent the spread of C. bovis and protect lab animal health.

Q: How Can I Start a C. Bovis decontamination or C. Bovis remediation?

A: QuipDecon Services by Quip Labs can play a critical role in eradicating C. Bovis from research labs or vivariums. QuipDecon Services are comprised of multiple components that include Quip Laboratories’ proprietary chemistries, state-of-the-art equipment and proven methodologies can help make C. Bovis remediation simple. As industry leaders in biosafety and facility hygiene, we can even provide guidance for design, monitoring, testing and education of both facility staff and researchers.

Working with an industry leader like Quip Labs can ensure that there’s very little operational interruption, and that all proper decontamination and verification steps are taken to eliminate the risks to research that C. Bovis poses.

Ready To Order?

Ready to Order Products that Kill Cornyebacterium bovis?

Click to sort all products by this claim!

Click Here!