Efficacy of Wex-cide 128 Against Prion Strains
Study: Efficacy of Wex-cide 128 disinfectant against multiple prion strains
Estimated time to read the full study: 30 min
Prion diseases, such as Creutzfeldt-Jakob Disease (CJD), chronic wasting disease (CWD), bovine spongiform encephalopathy (BSE), and scrapie, pose unique challenges for inactivation due to their resistance to common methods. This study sought to evaluate the effectiveness of Wex-cide 128, a phenolic disinfectant, against prions from various species compared to a similar product, Environ LpH (eLpH).
- The results indicate that Wex-cide 128 is highly effective against prions from hamsters, cervids, and mice, reducing infectivity by 4.0–5.5 logs.
- However, it showed limited efficacy against human sporadic CJD, reducing infectivity by only 1.25–1.50 logs, highlighting the need for strain-specific inactivation methods.
- Importantly, Wex-cide 128 emerges as a viable alternative for most prion species, offering a safer and more practical choice for prion decontamination in research, healthcare, and wildlife settings.
In essence, Wex-Cide 128 emerges as a promising alternative for mitigating prion contamination across various species. Its strengths lie in providing a safer and more pragmatic choice for prion decontamination, particularly in research environments.
Characteristics of Wex-Cide 128:
- Appearance: Clear to slightly cloudy transparent liquid
- Odor: Light citrus
- pH: 2.50 – 2.90
- Water solubility: Complete (100%)
- Non-dermal irritant
- Exhibits virucidal, germicidal, fungicidal, and tuberculocidal efficacy
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